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Relevant bibliographies by topics / Tryptanthrin

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Academic literature on the topic 'Tryptanthrin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Tryptanthrin"

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Frolova, Svetlana G., Ksenia M. Klimina, Ravinder Kumar, et al. "Identification of Mutations Conferring Tryptanthrin Resistance to Mycobacterium smegmatis." Antibiotics 10, no. 1 (2020): 6. http://dx.doi.org/10.3390/antibiotics10010006.

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Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a global burden, responsible for over 1 million deaths annually. The emergence and spread of drug-resistant M. tuberculosis strains (MDR-, XDR- and TDR-TB) is the main challenge in global TB-control, requiring the development of novel drugs acting on new biotargets, thus able to overcome the drug-resistance. Tryptanthrin is a natural alkaloid, with great therapeutic potential due to its simple way of synthesis and wide spectrum of biological activities including high bactericidal activity on both drug-susceptible and MDR M. tuberculos

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Krivogorsky, Bogdana, Peter Grundt, Robert Yolken, and Lorraine Jones-Brando. "Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs." Antimicrobial Agents and Chemotherapy 52, no. 12 (2008): 4466–69. http://dx.doi.org/10.1128/aac.00903-08.

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ABSTRACT New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

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Zhu, Xingang, Xuelian Zhang, Guo Ma, Junkai Yan, Honghai Wang, and Qing Yang. "Transport Characteristics of Tryptanthrin and its Inhibitory Effect on P-gp and MRP2 in Caco-2 Cells." Journal of Pharmacy & Pharmaceutical Sciences 14, no. 3 (2011): 325. http://dx.doi.org/10.18433/j3501w.

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Purpose. Tryptanthrin, an indole quinazoline alkaloid with multiple medical activities, has been recently under preclinical development as an anti-tuberculosis and anti-tumor drug. The aims of this study are to characterize the intestinal transport of tryptanthrin in Caco-2 cells, to determine whether P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) are involved in this issue, and to evaluate the potential influence of tryptanthrin on the function of P-gp and MRP2. Methods. Transport assays of tryptanthrin were performed in Caco-2 monolayers with or without the supple

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Zeng, Qingfang, Cairong Luo, Junlae Cho, et al. "Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment." Acta Pharmaceutica 71, no. 2 (2020): 245–66. http://dx.doi.org/10.2478/acph-2021-0020.

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Abstract Tryptanthrin is an indole quinazoline alkaloid from the indigo-bearing plants, such as Isatis indigotica Fort. Typically, this natural compound shows a variety of pharmacological activities such as antitumor, antibacterial, anti-inflammatory and antioxidant effects. This study was conducted to assess the antitumor activity of tryptanthrin in breast cancer models both in vitro and in vivo, and to explore the important role of the inflammatory tumor microenvironment (TME) in the antitumor effects of tryptanthrin. Human breast adenocarcinoma MCF-7 cells were used to assess the antitumor

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Garcia, Andreza R., Yasmin P. G. Silva-Luiz, Celuta S. Alviano, Daniela S. Alviano, Alane B. Vermelho, and Igor A. Rodrigues. "The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death in Leishmania spp." Tropical Medicine and Infectious Disease 7, no. 6 (2022): 112. http://dx.doi.org/10.3390/tropicalmed7060112.

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Leishmaniasis is a vector-borne disease against which there are no approved vaccines, and the treatment is based on highly toxic drugs. The alkaloids consist of a chemical class of natural nitrogen-containing substances with a long history of antileishmanial activity. The present study aimed at determining the antileishmanial activity and in silico pharmacokinetic and toxicological potentials of tryptanthrin alkaloid. The anti-Leishmania amazonensis and anti-L. infantum assays were performed against both promastigotes and intracellular amastigotes. Cellular viability was determined by parasite

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Tripathi, Vishwa Deepak. "Natural Product Inspired Synthesis of Tryptanthrin Analogues as Potential Antimalarial Agents." Asian Journal of Organic & Medicinal Chemistry 5, no. 4 (2020): 348–54. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p302.

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A new series of tryptanthrin analogues have been synthesized as potential antimalarial molecules. Synthesis of tryptanthrin aminoalkyl derivatives have been achieved via alkylation of oxime functionality of tryptanthrin derivatives by various alkyl amino pharmacophoric chains. 21-Membered small library of tryptanthrin aminoalkyl analogues were synthesized with variation in both parent natural alkaloid and in amino alkyl side chains. Synthesized compounds were fully characterized with 1H & 13C NMR, IR spectroscopy. Further all the members were screened for their antimalarial potential again

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Tsai, Yu-Chi, Chia-Lin Lee, Hung-Rong Yen, et al. "Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63." Biomolecules 10, no. 3 (2020): 366. http://dx.doi.org/10.3390/biom10030366.

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Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of S. cusia leaf contains chemical components such as β-sitosterol, indirubin, tryptanthrin, betulin, indigodole A, and indigodole B that have diverse biological activities. However, the antiviral action of S. cusia leaf and its components against human coronavirus remains to be elucidated. Human coronavirus NL63 infection is frequent among immunocompromised individuals, young children, and in the elderly. This study investigated the anti-Human coronavirus

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Costa, Fabio Luiz Paranhos, Sidnei Bessa de Oliveira Fernandes, Catharina Eccard Fingolo, et al. "Experimental and Theoretical Nuclear Magnetic Resonance Data from Tryptanthrin, an Alkaloid with Potential Activity Against Human Coronavirus." Advanced Science, Engineering and Medicine 12, no. 7 (2020): 963–69. http://dx.doi.org/10.1166/asem.2020.2638.

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Coronaviruses belong to the subfamily Coronavirinae, which are large viruses with a single Ribonucleic acid tape and a nucleocapsid. In a recent study it was found that the molecule of tryptanthrin has antiviral potential against human coronavirus NL63. In this work, we used a combination of theoretical techniques with experimental nuclear magnetic resonance data to assist in the structural characterization of the Tryptanthrin molecule. Tryptanthrin was extracted from Couroupita guianensis leaves. The theoretical calculations of hydrogen-1, homonuclear spin–spin coupling constants and the quan

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Dhandapani, Manoj, and Dheepan George. "In Vitro Study of Tryptanthrin and its Derivatives: A Potent Alkaloid Compound from Fluorescent Bacteria Pseudomonas sps in Anticancer Effects through Drug Design." Biosciences Biotechnology Research Asia 22, no. 2 (2025): 811–18. https://doi.org/10.13005/bbra/3405.

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ABSTRACT: Tryptanthrin, a naturally occurring indoloquinazoline alkaloid, exhibits remarkable anticancer potential. This study explores the isolation of Pseudomonas spp. from soil as a novel microbial source of tryptanthrin and its derivatives, followed by comprehensive in vitro and in silico analyses to evaluate their anticancer activity. Soil samples were collected and processed through serial dilution to isolate fluorescent Pseudomonas species, which were then identified using morphological, biochemical, and molecular (DNA extraction and sequencing) techniques. Tryptanthrin was extracted fr

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Zhong, Yi-ning, Yan Zhang, Yun-qiong Gu, Shi-yun Wu, Wen-ying Shen, and Ming-xiong Tan. "NovelFeIIandCoIIComplexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA." Bioinorganic Chemistry and Applications 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5075847.

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Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid fromIsatis. Two novelFeIIandCoIIcomplexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA. This study may potentially serve as the basis of future rational design of m

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Dissertations / Theses on the topic "Tryptanthrin"

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Yiu, Nai Sum. "Immunomodulatory effects of tryptanthrin on human bronchial epithelial cells." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/586.

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Chiu, I.-Fan, and 邱一帆. "I. The apoptotic activity of tryptanthrin derivatives in MCF7 cells II. Inhibition of TCDD-induced aryl hydrocarbon receptor translocation by tryptanthrin derivative DQ181." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/19816042560757980017.

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碩士<br>國立臺灣大學<br>藥學研究所<br>89<br>I. The apoptotic activity of tryptanthrin derivatives in MCF7 cells Tryptanthrin, indolo[2,1-b]quinazolin-6,12-dione, is a coplanar four-fused ring compound which contains N-phenyl-quinazoline skeleton similar to 2-phenyl-naphthalene. It was illustrated that compounds containing coplanar 2-phenyl-naphthalene skeleton exhibit different biological activites, while the bioactivities would be decreased or lost in unplanar structures. For example, batracylin, containing 2-phenyl-quinolone skeleton,inhibits the growth of carcinoma cell lines. In previous dat

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"Modulatory effects of tryptanthrin on the murine myeloid leukemia cells." 2008. http://library.cuhk.edu.hk/record=b5893599.

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Chan, Hoi Ling.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references (leaves 206-220).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABBREVIATIONS --- p.ii<br>ABSTRACT --- p.viii<br>撮要 --- p.xii<br>PUBLICATIONS --- p.xiv<br>TABLE OF CONTENTS --- p.xv<br>Chapter CHAPTER 1: --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Hematopoiesis & Leukemia --- p.1<br>Chapter 1.1.1 --- An Overview on Hematopoiesis Development --- p.1<br>Chapter 1.1.2 --- Leukemia --- p.6<br>Chapter 1.1.2.1 --- General Symptoms of Leukemia --- p.7<br>C

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Lin, Yeh-Ssu, and 林曄思. "The Effect of Tryptanthrin in MCF-7 Breast Cancer Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/08668569688413462113.

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碩士<br>國立臺灣大學<br>藥學研究所<br>97<br>Multidrug resistance (MDR), the resistance of tumor cells to anticancer agents, remains a major cause of treatment failure for cancer patients. MDR usually occurs with alteration of function and expression of some proteins and enzymes, for example P-gp (P-glycoprotein), MRP (multidrug resistance-related protein), topoisomerase and glutathione. Recently, the genes which show differential expressions in MCF-7/WT and its doxorubicin-resistant counterpart MCF-7/ADR include ER-α (estrogen receptor α), ER-β (estrogen receptor β), PR (progesterone receptor), VEGF（vascul

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Danz, Henning. "Untersuchungen zur antiinflammatorischen Wirkung und zur Analytik von Tryptanthrin in Isatis tinctoria L. /." 2001. http://www.gbv.de/dms/bs/toc/328938807.pdf.

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Chung, Chia-Hua, and 鍾佳華. "Effects of tryptanthrin on human hepatoma growth in vitro and in vivo." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/81248671303080476799.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>99<br>Hepatocellular carcinoma is a common tumor in Asia and Africa area. Tryptanthrin is a weakly basic alkaloid and has been reported to have various functions, such as anti-microorganisms, anti-parasites, immunomodulatory, anti-inflammatory and anti-tumor activity in vitro. In this study, we examined the efficacy of tryptanthrin in suppression hepatoma growth and further investigated the mechanism by which tryptanthrin alter tumor cell growth. Tryptanthrin significantly inhibited human hepatoma cell proliferation in vitro. However, our data showed that tr

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曾詩韻. "The mechanism of tryptanthrin derivatives DQ150 and EY083 on inhibition of multidrug resistance." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/04382688704669895471.

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碩士<br>國立臺灣大學<br>藥學研究所<br>88<br>The resistance of tumor cells to anticancer agents remains a major cause of treatment failure for cancer patients. Agents as adjuvants to overcome MDR become a new trend in chemotherapy. We have evaluated the tryptanthrin derivatives DQ150 and EY083 for their reversing activity against P-glycoprotein-(P-gp) and MRP-mediated MDR in breast cancer cell lines MCF7, adriamycin-resistant MCF7/adr and etoposide-resistant MCF7/vp. Using MTT assay, 10-6M of DQ150 and EY083 had a 6-fold and 2-fold decrease in adriamycin IC50, respectively, in MCF7/adr. At mRNA l

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Yu, Sung-Tsai, and 尤松材. "The mechanism of tryptanthrin derivatives DQ150 and EY083 on inhibition of multidrug resistance." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/68672566595965765092.

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碩士<br>國立臺灣大學<br>藥學研究所<br>89<br>Chemotherapy is a common and effective treatment for tumors. However, the resistance of tumor cells to anticancer agents remains a major cause of treatment failure in cancer patients. Increased expression in tumor cells of plasma membrane proteins such as the P-glycoprotein (P-gp) or the multidrug resistance-associated protein 1 (MRP1) is often associated with such multidrug resistance (MDR) phenotype. P-glycoprotein and MRP1 both belong to membrane transport proteins of the large ATP-binding cassette (ABC) superfamily but share less than 20% amino acid identity.

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Chang, Hsin Ning, and 張心寧. "The anti-psoriatic effect and mechanism of indigo naturalis and its active component, tryptanthrin." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107CGU05521026%22.&searchmode=basic.

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Pinheiro, Daniela Ribeiro. "Synthesis, photophysical and electrochemical studies on tryptanthrin and indigo derivatives. Historic molecules with modern applications." Doctoral thesis, 2021. http://hdl.handle.net/10316/95405.

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Tese no âmbito do Doutoramento em Química, ramo de especialização em Fotoquímica, apresentada ao Departamento de Química da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Indigo, an iconic molecule of colour, is included in the most ancient and important natural dyes used by mankind. The longevity as a colourant and unique properties of this compound are related with its high (photo)stability which is linked to a rapid proton transfer in the excited state (ESPT). In the past few years, indigo and its derivatives have gained renewed interest due to applications in several fie

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Book chapters on the topic "Tryptanthrin"

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Schrenk, Dieter, Dirk Riebniger, Markus Till, Silvia Vetter, and Hans-Peter Fiedler. "Tryptanthrins and Other Tryptophan-Derived Agonists of the Dioxin Receptor." In Advances in Experimental Medicine and Biology. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4709-9_51.

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Cunha, Carla, and J. Sérgio Seixas de Melo. "The molecules of colour. New structural derivatives from indigo: tryptanthrin and indirubin." In Photochemistry. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837672301-00045.

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Two compounds, which are structurally related to indigo, tryptanthrin and indirubin, are here described in the context of recent findings in this new chapter of the Molecules of Colour. The two are naturally occurring compounds, with diversified applications. Indirubin, the red isomer of the blue indigo, shows, in comparison with indigo, a more efficient radiationless decay process, whose mechanism has been recently detailed and constitutes a step forward in the complexity of indigo’s deactivation and associated photostability. In contrast with indigo, tryptanthrin, which can be synthetically

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Shankar, G. Mohan, Jayesh Antony, and Ruby John Anto. "Quercetin and Tryptanthrin." In Mechanism of the Anticancer Effect of Phytochemicals. Elsevier, 2015. http://dx.doi.org/10.1016/bs.enz.2015.05.001.

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Popov, Alekleksandr, Tatyana Rutckova, Olga Styshova, Andrey Shchekotikhin, and Valentin Stonik. "Prospects for the Application of Tryptanthrin and Mostotrin Alkaloids in Therapy and Control of Inter-Specific Interactions in Various Symbiotic Systems: A Review." In Chemistry and Biochemistry: Research Progress Vol. 6. BP International, 2025. https://doi.org/10.9734/bpi/cbrp/v6/5626.

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Conference papers on the topic "Tryptanthrin"

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Boitsov, Vitali M., Diana K. Latypova, Stanislav V. Shmakov, Alexander V. Stepakov, and Nickolay A. Knyazev. "Identification of spiro-fused pyrrolo[3,4-a]pyrrolizines and tryptanthrines as potential antitumor agents: Synthesis and initial <em>in vitro</em> evaluation." In 7th International Electronic Conference on Medicinal Chemistry. MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11432.

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