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Relevant bibliographies by topics / Signalling pathway

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Academic literature on the topic 'Signalling pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Signalling pathway"

1

Lojk, Jasna, and Janja Marc. "Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology." International Journal of Molecular Sciences 22, no. 19 (2021): 10840. http://dx.doi.org/10.3390/ijms221910840.

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The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tight regulation of bone tissue homeostasis. This enables maintenance of optimal mineral density, tissue healing and adaptation to changes in bone loading. While the role of the canonical/β-catenin Wnt signalling pathway in bone homeostasis is relatively well researched, Wnt ligands can also activate se

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Wang, Lin-Qing, Jing-Cai Liu, Chun-Lei Chen, et al. "Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tensin homologue (PTEN)/AKT pathways." Reproduction, Fertility and Development 28, no. 6 (2016): 700. http://dx.doi.org/10.1071/rd14212.

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The growth of oocytes and the development of follicles require certain pathways involved in cell proliferation and survival, such as the phosphatidylinositol 3-kinase (PI3K) pathway and the Notch signalling pathway. The aim of the present study was to investigate the interaction between Notch and the PI3K/AKT signalling pathways and their effects on primordial follicle recruitment. When the Notch pathway was inhibited by L-685,458 or N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycinet-butyl ester (DAPT) in vitro, the expression of genes in the pathway and the percentage of oocytes in grow

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Sanz-Ezquerro, Juan José, and Ana Cuenda. "p38 Signalling Pathway." International Journal of Molecular Sciences 22, no. 3 (2021): 1003. http://dx.doi.org/10.3390/ijms22031003.

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p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...]

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Gomi, Kenji, and Makoto Matsuoka. "Gibberellin signalling pathway." Current Opinion in Plant Biology 6, no. 5 (2003): 489–93. http://dx.doi.org/10.1016/s1369-5266(03)00079-7.

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Ma, Chen-Yu, Yu-Qian Ma, and Min Deng. "Mechanism of Zhen Wu Decoction in the Treatment of Heart Failure Based on Network Pharmacology and Molecular Docking." Evidence-Based Complementary and Alternative Medicine 2022 (March 15, 2022): 1–10. http://dx.doi.org/10.1155/2022/4877920.

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Heart failure (HF) is a serious manifestation or advanced stage of various cardiovascular diseases, and its mortality and rehospitalization rate are still on the rise in China. Based on the network pharmacology method, 59 components of Zhen Wu decoction (ZWD) and 83 target genes related to HF were obtained. Through the PPI network, four potential therapeutic targets were identified: AKT1, IL6, JUN, and MAPK8. The beneficial components of ZWD might intervene HF through the AGE-RAGE signalling pathway in the diabetes component, fluid shear stress and atherosclerosis, the TNF signalling pathway,

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Langiu, Monica, Philipp Bechstein, Sonja Neumann, Gabriele Spohn, and Erik Maronde. "Regulation of CRE-Dependent Transcriptional Activity in a Mouse Suprachiasmatic Nucleus Cell Line." International Journal of Molecular Sciences 23, no. 20 (2022): 12226. http://dx.doi.org/10.3390/ijms232012226.

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We evaluated the signalling framework of immortalized cells from the hypothalamic suprachiasmatic nucleus (SCN) of the mouse. We selected a vasoactive intestinal peptide (VIP)-positive sub-clone of immortalized mouse SCN-cells stably expressing a cAMP-regulated-element (CRE)-luciferase construct named SCNCRE. We characterized these cells in terms of their status as neuronal cells, as well as for important components of the cAMP-dependent signal transduction pathway and compared them to SCN ex vivo. SCNCRE cells were treated with agents that modulate different intracellular signalling pathways

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Jarnæss, E., and K. Taskén. "Spatiotemporal control of cAMP signalling processes by anchored signalling complexes." Biochemical Society Transactions 35, no. 5 (2007): 931–37. http://dx.doi.org/10.1042/bst0350931.

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Ligand-induced changes in cAMP concentration vary in duration, amplitude and extension into the cell. cAMP microdomains are shaped by adenylate cyclases that form cAMP as well as PDEs (phosphodiesterases) that degrade cAMP. Various extracellular signals converge on the cAMP/PKA (protein kinase A) pathway through ligand binding to GPCRs (G-protein-coupled receptors) and the cAMP/PKA pathway is therefore tightly regulated on several levels to maintain specificity in the multitude of signal inputs. AKAPs (A-kinase-anchoring proteins) target PKA to specific substrates and distinct subcellular comp

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Joshipura, Akshat, and Salmataj S. A. Salmataj S A. "diopathic Pulmonary Fibrosis: A Review on Molecular and Cellular Mechanisms." Biomedical and Pharmacology Journal 15, no. 1 (2022): 291–97. http://dx.doi.org/10.13005/bpj/2366.

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Idiopathic pulmonary fibrosis is a progressive disease characterized by extracellular matrix accumulation and altered mechanical properties of lung tissue. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is attracting considerable attention due to disease acceleration and substantial mortality. The biomechanical properties of tissues are sensed and responded to by mechanotransduction pathways that facilitate sensing of changes in mechanical cues by tissue resident cells and convert the mechanical signals into downstream biochemical signals. In this review pathways such as Wnt/β-ca

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Babonis, Leslie S., and Mark Q. Martindale. "Phylogenetic evidence for the modular evolution of metazoan signalling pathways." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1713 (2017): 20150477. http://dx.doi.org/10.1098/rstb.2015.0477.

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Communication among cells was paramount to the evolutionary increase in cell type diversity and, ultimately, the origin of large body size. Across the diversity of Metazoa, there are only few conserved cell signalling pathways known to orchestrate the complex cell and tissue interactions regulating development; thus, modification to these few pathways has been responsible for generating diversity during the evolution of animals. Here, we summarize evidence for the origin and putative function of the intracellular, membrane-bound and secreted components of seven metazoan cell signalling pathway

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Agostino, Mark, and Sebastian Öther-Gee Pohl. "The structural biology of canonical Wnt signalling." Biochemical Society Transactions 48, no. 4 (2020): 1765–80. http://dx.doi.org/10.1042/bst20200243.

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The Wnt signalling pathways are of great importance in embryonic development and oncogenesis. Canonical and non-canonical Wnt signalling pathways are known, with the canonical (or β-catenin dependent) pathway being perhaps the best studied of these. While structural knowledge of proteins and interactions involved in canonical Wnt signalling has accumulated over the past 20 years, the pace of discovery has increased in recent years, with the structures of several key proteins and assemblies in the pathway being released. In this review, we provide a brief overview of canonical Wnt signalling, f

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Dissertations / Theses on the topic "Signalling pathway"

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Baumann, Fabrizio. "Cell signalling through the Wnt pathway /." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04baumann_f.pdf.

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Ng, Ming-him. "Ras signalling pathway and MLL-rearranged leukaemias." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3643419X.

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Buchanan, V. S. "Components of the Ret oncogene signalling pathway." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597050.

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The Multiple Endocrine Neoplasia type 2 syndromes are dominantly inherited cancer syndromes of tumour formation (affecting the thyroid C-cells, the adrenal chromaffin cells and the parathyroids) and developmental abnormalities. Germline activating mutations in the <I>ret</I> proto-oncogene, encoding a receptor tyrosine kinase (RTK), have previously been shown to predispose to MEN 2. In order to understand how Ret mutations cause MEN 2, it is important to understand the biology of Ret, including the signal transduction pathways recruited by both the normal and mutant Ret receptors. I have attem

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Ng, Ming-him, and 吳明謙. "Ras signalling pathway and MLL-rearranged leukaemias." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37238656.

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Horton, Caroline Alison. "Computational modelling of cell signalling pathway dynamics." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433816.

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Pogson, Mark. "Modelling the intracellular NF-κB signalling pathway". Thesis, University of Sheffield, 2006. http://etheses.whiterose.ac.uk/10353/.

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NF-κB is a transcription factor which is central to the regulation of genes involved in inflammatory and immune responses. Understanding the operation of NF-κB and its associated intracellular signalling pathway is essential in order to control a wide range of chronic inflammatory diseases, including asthma and rheumatoid arthritis. Abnormalities in the pathway are present in a variety of human cancers and may also affect the pathogenesis of Alzheimer's disease. Computational modelling of the signalling pathway is necessary to overcome the practical limitations of biological experiments and to

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Annavarapu, Srinivas Rao. "Characterisation of Wnt signalling pathway in rhabdomyosarcoma." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009225/.

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Introduction: Rhabdomyosarcoma (RMS) remains one of the most challenging tumours in paediatric oncology, accounting for around 5% of all malignant paediatric tumours. Of the two major subtypes of RMS, embryonal and alveolar, the latter portends a poorer clinical outcome. Canonical Wnt signalling pathway is an important evolutionarily conserved signalling pathway that is required for muscle development and embryonal somite patterning. β-Catenin is a potent nuclear transcriptional activator and is the central effector of the canonical Wnt signalling pathway. Interestingly, constitutional activat

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Brightman, Frances A. "Computer simulation of a growth factor signal transduction pathway." Thesis, Oxford Brookes University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340868.

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Filippi, Marta Cristina. "Signalling pathway in appressorium formation in Magnaporthe grisea." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1109.

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We identified a synthetic hexapeptide that blocks Magnaporthe grisea appressorium formation, in artificial hydrophobic surface. The results suggest that peptides interfere with surface recognition. M. grisea non pathogenic pth1 mutants were complemented by N. crassa orthologous gene suggesting that the biochemical function of pth1 has not evolved specifically to play a role in appressorium development.

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Hardcastle, Zoe. "The Sonic Hedgehog signalling pathway in tooth development." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368160.

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Books on the topic "Signalling pathway"

1

Bhimani, Munsif Ali. Detecting mediators of the Flk-1 signalling pathway by mRNA differential display. National Library of Canada, 1998.

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Nguyen, Melody Hong Hanh. TEL-Jak2 chromosomal translocations and the PI3' kinase and PKB signalling pathway. National Library of Canada, 2000.

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Rizza, Annalisa. Identification of components in the BBX24 light signalling pathway in Arabidopsis thaliana. s.n.], 2013.

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O, Pickens Charles, ed. Cell apoptotic signalling pathways. Nova Biomedical Books, 2007.

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1943-, Lavin Martin, and Watters Dianne 1952-, eds. Signalling pathways in apoptosis. Harwood Academic, 1999.

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Chadwick, Derek J., and Jamie Goode, eds. Signalling Pathways in Acute Oxygen Sensing. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/9780470035009.

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Foundation, Novartis. Signalling Pathways in Acute Oxygen Sensing. John Wiley & Sons, Ltd., 2006.

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Tuominen-Gustafsson, Helena Birgitta. Calcium signalling pathways in human neutrophils. Åbo Akademis Förlag, 1998.

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Symposium on Signalling Pathways in Acute Oxygen Sensing (2005 Novartis Foundation). Signalling pathways in acute oxygen sensing. John Wiley, 2006.

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10

Dua, Kamal, Raimar Löbenberg, Ângela Cristina Malheiros Luzo, Shakti Shukla, and Saurabh Satija, eds. Targeting Cellular Signalling Pathways in Lung Diseases. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6827-9.

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Book chapters on the topic "Signalling pathway"

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Robert, Jacques. "Cytokines Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_4.

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Robert, Jacques. "TGFβ Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_5.

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Robert, Jacques. "Wnt Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_7.

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Robert, Jacques. "Notch Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_8.

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Robert, Jacques. "Hedgehog Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_9.

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Bashri, Gausiya, Abreeq Fatima, Shikha Singh, and Sheo Mohan Prasad. "Interplay of Brassinosteroids and Auxin for Understanding of Signaling Pathway." In Brassinosteroids Signalling. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5743-6_8.

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Robert, Jacques. "MAP Kinase Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_2.

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Toni, Tina, Juliane Liepe, and Michael P. H. Stumpf. "Inference of Signalling Pathway Models." In Handbook of Statistical Systems Biology. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119970606.ch21.

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Robert, Jacques. "Phosphatidylinositol 3-Kinase Pathway." In Textbook of Cell Signalling in Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14340-8_3.

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Holik, Aliaksei, and Alan R. Clarke. "Targeting Wnt Signalling in Cancer." In Targeting the Wnt Pathway in Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-8023-6_8.

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Conference papers on the topic "Signalling pathway"

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Ng, Chi Kit, Jianqiao Long, Muran Tang, Jichun Li, and Mingming Quan. "Exploring AI-Driven Drug Repurposing Strategies Targeting ErbB Signalling Pathway for Brain Cancer Therapy." In 2024 IEEE International Conference on Cybernetics and Intelligent Systems (CIS) and IEEE International Conference on Robotics, Automation and Mechatronics (RAM). IEEE, 2024. http://dx.doi.org/10.1109/cis-ram61939.2024.10673264.

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Spirina, L. V., Y. A. Usynin, I. V. Kondakova, Z. A. Yurmazov, E. M. Slonimskaya, and E. S. Kolegova. "The AKT-mTOR signalling pathway in kidney cancer tissues." In NEW OPERATIONAL TECHNOLOGIES (NEWOT’2015): Proceedings of the 5th International Scientific Conference «New Operational Technologies». AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4936067.

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Simone Clement, Michelle, Boe Sandahl Sorensen, Sinead Cuffe, Stephen Finn, and Kathy Gately. "Targeting STAT3 pathway signalling in EGFR TKI resistant NSCLC." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.330.

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Woodcock, Hannah, Simon Peace, Carmel Nanthakumar, Toby Maher, Paul Mercer та Rachel Chamers. "mTOR signalling is an essential pathway for TGF-β1induced collagen synthesis". У Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa935.

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Tournier, Laurent, and Madalena Chaves. "Operational interactions in genetic networks: Application to an apoptosis signalling pathway." In 2009 European Control Conference (ECC). IEEE, 2009. http://dx.doi.org/10.23919/ecc.2009.7074679.

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Van der Ploeg, P., W. Verhaegh, J. De Hullu, A. Van der Stolpe, and J. Piek. "PO-138 Hedgehog signalling pathway activity in high-grade serous ovarian carcinoma." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.662.

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O'Toole, DP, PD Hassett, AM Leo, BD Higgins та JG Laffey. "Molecular Effects of Hypercapnic Acidosis on the NF-κB Intracellular Signalling Pathway." У American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1931.

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Tung, C. H., J. M. Hsu, M. C. Lu, and N. S. Lai. "AB0055 Hydroxychloroquine inhibits soluble cd154 production through ca2+ and pkc signalling pathway." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3172.

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Seaton, Daniel D., and J. Krishnan. "Modelling the Influence of Allostery on Crosstalk in the Phosphatidylinositol Signalling Pathway." In Intelligent Systems and Control. ACTAPRESS, 2011. http://dx.doi.org/10.2316/p.2011.742-046.

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Williams, Richard A., Jon Timmis та Eva E. Qwarnstrom. "Investigating IKK dynamics in the NF-κB signalling pathway using X-Machines". У 2017 IEEE Congress on Evolutionary Computation (CEC). IEEE, 2017. http://dx.doi.org/10.1109/cec.2017.7969320.

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Reports on the topic "Signalling pathway"

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Luo, Fang, han-han Chen, Jun-Jie Feng, et al. Effect of acupuncture on insulin signalling pathway and mitochondrial AMPK pathway in animal model of type 2 diabetes mellitus:A systematic evaluation and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.11.0086.

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Friedman, Haya, Julia Vrebalov, James Giovannoni, and Edna Pesis. Unravelling the Mode of Action of Ripening-Specific MADS-box Genes for Development of Tools to Improve Banana Fruit Shelf-life and Quality. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592116.bard.

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Fruit deterioration is a consequence of a genetically-determined fruit ripening and senescence programs, in which developmental factors lead to a climacteric rise of ethylene production in ethylene-sensitive fruits such as tomato and banana. Breeding of tomato with extended fruit shelf life involves the incorporation of a mutation in RIN, a MADS-box transcription factor participating in developmental control signalling of ripening. The RIN mode of action is not fully understood, and it may be predicted to interact with other MADS-box genes to execute its effects. The overall goal of this study

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Wagner, D. Ry, Eliezer Lifschitz, and Steve A. Kay. Molecular Genetic Analysis of Flowering in Arabidopsis and Tomato. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7585198.bard.

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The primary objectives for the US lab included: the characterization of ELF3 transcription and translation; the creation and characterization of various transgenic lines that misexpress ELF3; defining genetic pathways related to ELF3 function regulating floral initiation in Arabidopsis; and the identification of genes that either interact with or are regulated by ELF3. Light quality, photoperiod, and temperature often act as important and, for some species, essential environmental cues for the initiation of flowering. However, there is relatively little information on the molecular mechanisms

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Miller, Gad, and Jeffrey F. Harper. Pollen fertility and the role of ROS and Ca signaling in heat stress tolerance. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598150.bard.

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The long-term goal of this research is to understand how pollen cope with stress, and identify genes that can be manipulated in crop plants to improve reproductive success during heat stress. The specific aims were to: 1) Compare heat stress dependent changes in gene expression between wild type pollen, and mutants in which pollen are heat sensitive (cngc16) or heat tolerant (apx2-1). 2) Compare cngc16 and apx2 mutants for differences in heat-stress triggered changes in ROS, cNMP, and Ca²⁺ transients. 3) Expand a mutant screen for pollen with increased or decreased thermo-tolerance. These aims

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Yu, Mei, Pengyu Wang, Binbin Li, et al. NRSF Negatively Regulates Microglial Pro-Inflammatory Activation. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.20.02.

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Microglial activation contributes to neurological disorders like Parkinson’s disease (PD), and modulating this activation is a potential therapeutic approach. The neuron-restrictive silencer factor (NRSF) functions as a negative regulator of gene transcription through epigenetic modifications. While previous research has primarily examined the role of NRSF in neuronal differentiation and injury, emerging evidence indicates that NRSF also plays a significant role in maintaining the phenotype of glial cells. In this study, we explored the role and underlying mechanisms of NRSF in lipopolysacchar

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Sionov, Edward, Nancy Keller, and Shiri Barad-Kotler. Mechanisms governing the global regulation of mycotoxin production and pathogenicity by Penicillium expansum in postharvest fruits. United States Department of Agriculture, 2017. http://dx.doi.org/10.32747/2017.7604292.bard.

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The original objectives of the study, as defined in the approved proposal, are: To characterize the relationship of CreA and LaeA in regulation of P T production To understand how PacC modulates P. expansumpathogenicity on apples To examine if other secondary metabolites are involved in virulence or P. expansumfitness To identify the signaling pathways leading to PAT synthesis Penicilliumexpansum, the causal agent of blue mould rot, is a critical health concern because of the production of the mycotoxinpatulin (PAT) in colonized apple fruit tissue. Although PAT is produced by many Penicilliums

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